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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/14517/14
    A Novel Kinetic Spectrophotometric Method for the Determination of Dopamine in Biological and\nPharmaceutical Samples
    01-Jan-1970 Research 2014 : October - December
    M Reza Shishehbore, Adel Asgharpoor, N Nasirizadeh

    A sensitive and accurate method for quantitative determination of dopamine was introduced. The proposed method is based on\ninhibitory effect of dopamine on the oxidation of thionine by bromate in acidic media. The change in absorbance was followed\nspectrophotometrically at 601 nm. The dependence of sensitivity on the reaction variables was investigated and optimized to obtain\nthe maximum sensitivity. Under optimum experimental conditions, calibration curve was linear over the range 0.2ââ?¬â??103.3 ?gmL?1\nof dopamine.The relative standard deviations (n = 6) of 0.5, 1.0, 5.0, and 30.0 ?gmL?1 of dopamine were 1.13, 1.02, 0.99, and 0.97%,\nrespectively.The limit of detection was 0.057 ????gmL?1 of dopamine.The effect of diverse species was also investigated.Thedeveloped\nmethod was successfully applied for the determination of dopamine in pharmaceutical and biological samples.

    How to Cite this Article
    CC Compliant Citation: M. Reza Shishehbore, Adel\nAsgharpoor, and N. Nasirizadeh, â??A Novel Kinetic\nSpectrophotometric Method for the Determination of\nDopamine in Biological and Pharmaceutical Samples,â?\nJournal of Chemistry, vol. 2013, Article ID 819460, 6 pages,\n2013. doi:10.1155/2013/819460. Copyright © 2013 M. Reza Shishehbore et al. This article is distributed under the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly\ncited.
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